[Effect of renal artery stenting on the clinical and geriatric status of elderly patients with vasorenal hypertension.]

The study consists in determining the effect of renal artery stenting in patients with arterial hypertension in combination with renal artery stenosis on the dynamics of clinical and geriatric status in terms of such indicators as the number of drugs taken, cognitive status, determined by the MMSE scale, prevalence of the frequency of falls, psycho-emotional status by the Beck scale, the quality of sleep on the VAS scale, the index of age discrimination according to the E.Palmore ageism questionnaire, the quality of life according to the SF 36 questionnaire. The study involved 72 elderly patients with arterial hypertension in combination with renal artery stenosis. According to the results of the study, as a result of stenting of the renal arteries, there is a decrease in the number of drugs taken, an improvement in the cognitive status on the MMSE scale, a decrease in the frequency of falls, an improvement in the psycho-emotional status on the Beck scale, an improvement in the quality of sleep on the VAS scale, a decrease in the level of age discrimination, an increase in the quality of life according to questionnaire SF-36 on all scales.

[Determination of cytokines and adhesion molecules in elderly and senile patients with aortic valve calcification.]

A laboratory study of the cytokine profile and the content of the intercellular adhesion molecules was performed in 38 patients with initial signs of aortic hemilunus calcification. It has been determined that the content of IL-6 and IL-8 had significantly higher values compared with the control group, which indicates the direct role of nonspecific chronic inflammation in the development of calcifying aortic valve damage. A significantly lower content of sE-selectin was also identified, which may indicate the absence of activation of adhesion molecules at the initial stage of aortic valve calcification. Further study of the dynamics of sE- and sP-selectins content in the process of development of acceleration of blood flow in the aortic valve and the formation of stenosis is needed.

[Hybrid vascular interventions on the peripheral arteries in the treatment of critical ischemia in elderly patients.]

Peripheral arterial disease has a huge contribution to the overall mortality rate of the population, especially in the group of patients of old and old age. The likelihood of an adverse outcome is increased against a background with other possible nosological forms. In particular, the combination of peripheral atherosclerosis with diabetes mellitus very often manifests itself in the form of a multilevel lesion of the lower limb arteries. The treatment of such patients is very difficult, since the use of only open or endovascular approaches has its own contraindications and limitations, and cannot be used throughout the course of the lesion. The way out of this situation is the use of a hybrid approach, which consists in the combination of an open surgical reconstruction on the upper floors of the lesion and balloon angioplasty on the arteries of the lower leg. This approach allows you to use the advantages of both methods and achieve good results of treatment. The article presents the experience of treatment using a hybrid approach in elderly and senile patients with multilevel lesion of the lower limb arteries on the background of diabetes mellitus.

[Modern look at endovascular treatment bleeding the gastrointestinal tract in elderly patients.]

A literature review of the publications of foreign authors on the treatment of non-varicose bleeding from the upper gastrointestinal tract of elderly and senile patients is presented. The authors showed a modern view of the possibilities of endovascular hemostasis in comparison with a surgical operation with inefficiency of endoscopic hemostasis and characterized patients in whom it is possible this will be most effective.

[HYBRID REVASCULIZATION AS METHOD OF SURGICAL TREATMENT OF ISCHEMIC CORONARY DISEASE IN NUMEROUS LESIONS OF CORONARY BED].

Hybrid revasculization of myocardium combined the advantages of mammary-coronary bypass surgery and coronary arteries stenting. It presented itself as a perspective direction in treatment of ischemic coronary disease. The article provides the results of comparison of usage of hybrid revasculization of myocardium and aortocoronary bypass in 71 patients with multivessel coronary artery disease. The data obtained indicated, that hybrid approach allowed complete revasculization of the myocardium (as in case of aortocoronary bypass), fast recovery of the patient, shortening a hospital stay due to decrease of intra- and postoperative complications.

[Treatment of elderly patients with combination of coronary artery disease and aortic valve pathology].

Increasingly, there are patients with concomitant coronary artery disease and aortic valve, especially in elderly patients, who often have severe comorbidities and high surgical risk, which is undoubtedly a certain effect on the choice of method and tactics of treatment. Today, there are several approaches to the treatment of patients in this category, and all of them have certain advantages and disadvantages.

[Endovascular treatment of bifurcation lesions of the coronary arteries in patients of elderly age: a review of the literature No 1].

Stenting of coronary artery bifurcation lesions is one of the most difficult types of interventional procedures for coronary heart disease. The frequency of coronary artery bifurcation lesion occurs up to 20%. The article reflects a wide variety of types of classifications of coronary bifurcations compared with the basic classification for A. Medina. Having considered the arts of bifurcations stenting, from a provisional Tstenting to complex procedures culote and crush stenting, we advocate the use of bifurcation structures, especially in elderly and senile.

[Endovascular treatment of bifurcation lesions of the coronary arteries in elderly patients: a literature review N-2].

Intervention in bifurcation coronary arteries disease is complicated kind of endovascular treatment of coronary heart disease, especially in patients of elderly and senile age. Recently, in the practice of the operating surgeon there is a large choice of bifurcation coronary artery stents. This report contains the views, features and shortcomings of the presented bifurcation structures. Despite the fact that in the Russian Federation bifurcation stents are rarely implanted, their use can greatly simplify and accelerate interventional procedures, along with the decrease of peri- and postoperative complications.

[Features of antiagregant and anticoagulant therapy at a hybrid revascularization of a myocardium in elderly and senile patients].

The hybrid revascularization of a myocardium combines advantages of mammaro-coronary shunting and stenting of coronary arteries and represents the perspective direction in coronary heart disease treatment. This technique is of most value in patients of advanced and senile age, and also in patients of high surgical risk as it shows small injury, which enables to reduce and facilitate the postoperative period. However today, there is no single standard for the execution of these operations, in particular it is not clear, which scheme of antiagregant and anticoagulant therapy is worth adhering for greater efficiency of the procedures and patient safety.

[Hybrid methods in the treatment of heart disease in elderly and senile patients].

Hybrid technologies are becoming increasingly strong position in modern cardiac surgery. New standards and expanding the indications for use of these techniques are delivered. The advantages of hybrid interventions are to a substantial reduction in trauma patients during surgery, reducing the risk of both intra- and postoperative complications, death, the most important for the elderly and senile age.

[Theoretical substantiation and experience in vibromechanical dilatation of hollow organs]. / Teoreticheskoe obosnovanie i opyt primeneniia vibromekhanicheskoi dilatatsii polovogo organa.

The paper analyzes the principle of operation of a dilatation catheter, a device designed for expanding hollow organs. The organs (blood vessels, esophagus, cervix uteri through the cervical canal, uterine tubes) were the subject of investigation. The effective energy of action on the hollow organ wall in different catheter operations and the safety index for dilatation of hollow organs were defined. The aim of the study was to theoretically substantiate the clinical potentialities of the vibromechanical hollow organ dilatation.

[Anticholinesterase properties and metabolism of new thiophosphonates with a carboxy ester bond in the phosphoryl portion of the molecule]. / Antikholinesteraznye svoistva i metabolizm novykh tiofosfonatov s karboksiéfirnoi sviaz'iu v fosforil'noi chasti molekuly.

Introduction of the carboxyester bond into the phosphoryl part of thiophosphonate molecules did not affect their capacity to inhibit cholinesterases, but increased the rate of enzymatic detoxication of the preparations. The enzymatic turnover of the drugs studied occurred in rat tissues mainly be means of hydrolysis of the complex-ester bond. The carboxyesterase hydrolysis of these drugs was apparently carried out involving the unspecific enzyme aliesterase (EC 3.1.1.1.).

[Topography of the elements of the heart conduction system in the human]. / Topografiia élementov provodiashchei sistemy serdtsa cheloveka.

In 112 preparations of hearts from persons at the age of 18-87 years by means of the preparation method (77 hearts) and in histograms stained after Van Gieson, Mallory, Heidenhain and Masson (35 hearts), certain new data on the cardiac conduction system (CCS) have been obtained. A number of fasciculi connected with the sinuatrial and atrioventricular nodes have been revealed. The atrioventricular part of the CCS, as a more ancient one, is characterized by a more constant structure and topography. The sinuatrial part of the CCS, being phylogenetically younger, has a high degree of individual anatomical changeability.